1xuo

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xuo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUO FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xuo]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XUO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA1:(2R)-2-[3-ISOBUTYL-2,5-DIOXO-4-(QUINOLIN-3-YLMETHYL)-1,4-DIAZEPAN-1-YL]-N-METHYL-3-(2-NAPHTHYL)PROPANAMIDE'>LA1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LA1:(2R)-2-[3-ISOBUTYL-2,5-DIOXO-4-(QUINOLIN-3-YLMETHYL)-1,4-DIAZEPAN-1-YL]-N-METHYL-3-(2-NAPHTHYL)PROPANAMIDE'>LA1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cqp|1cqp]], [[1xdd|1xdd]], [[1xdg|1xdg]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1cqp|1cqp]], [[1xdd|1xdd]], [[1xdg|1xdg]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xuo RCSB], [http://www.ebi.ac.uk/pdbsum/1xuo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xuo RCSB], [http://www.ebi.ac.uk/pdbsum/1xuo PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Albert, R.]]
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[[Category: Albert, R]]
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[[Category: Ehrhardt, C.]]
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[[Category: Ehrhardt, C]]
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[[Category: Guo, Q.]]
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[[Category: Guo, Q]]
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[[Category: Hommel, U.]]
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[[Category: Hommel, U]]
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[[Category: Kallen, J.]]
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[[Category: Kallen, J]]
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[[Category: Myers, S.]]
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[[Category: Myers, S]]
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[[Category: Sabio, M.]]
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[[Category: Sabio, M]]
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[[Category: Wattanasin, S.]]
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[[Category: Wattanasin, S]]
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[[Category: Weckbecker, G.]]
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[[Category: Weckbecker, G]]
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[[Category: Welzenbach, K.]]
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[[Category: Welzenbach, K]]
[[Category: I-domain]]
[[Category: I-domain]]
[[Category: Immune system]]
[[Category: Immune system]]
[[Category: Integrin]]
[[Category: Integrin]]

Revision as of 18:01, 24 December 2014

X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution

1xuo, resolution 1.80Å

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