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2xyh
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xyh RCSB], [http://www.ebi.ac.uk/pdbsum/2xyh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xyh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xyh RCSB], [http://www.ebi.ac.uk/pdbsum/2xyh PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CASP3_HUMAN CASP3_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.<ref>PMID:7596430</ref> <ref>PMID:21357690</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Caspase-3]] | [[Category: Caspase-3]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Ganesan, R | + | [[Category: Ganesan, R]] |
| - | [[Category: Grutter, M G | + | [[Category: Grutter, M G]] |
| - | [[Category: Jelakovic, S | + | [[Category: Jelakovic, S]] |
| - | [[Category: Mittl, P R | + | [[Category: Mittl, P R]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Docking]] | [[Category: Docking]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: In silico screening]] | [[Category: In silico screening]] | ||
Revision as of 18:03, 24 December 2014
CASPASE-3:CAS60254719
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