3wu4
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wu4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wu4 RCSB], [http://www.ebi.ac.uk/pdbsum/3wu4 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wu4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wu4 RCSB], [http://www.ebi.ac.uk/pdbsum/3wu4 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/C9QQ79_ECOD1 C9QQ79_ECOD1]] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, and UmuD. Its overproduction specifically inhibits translation trough at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system.[HAMAP-Rule:MF_01973] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 18:04, 24 December 2014
Oxidized-form structure of E.coli Lon Proteolytic domain
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