1qjj
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1qjj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Astacus_astacus Astacus astacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QJJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[1qjj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Astacus_astacus Astacus astacus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QJJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QJJ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HOA:HYDROXYAMINE'>HOA</scene></td></tr> | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=HOA:HYDROXYAMINE'>HOA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ast|1ast]], [[1iaa|1iaa]], [[1iab|1iab]], [[1iac|1iac]], [[1iad|1iad]], [[1iae|1iae]], [[1qji|1qji]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ast|1ast]], [[1iaa|1iaa]], [[1iab|1iab]], [[1iac|1iac]], [[1iad|1iad]], [[1iae|1iae]], [[1qji|1qji]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Astacin Astacin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.21 3.4.24.21] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Astacin Astacin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.21 3.4.24.21] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qjj RCSB], [http://www.ebi.ac.uk/pdbsum/1qjj PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qjj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qjj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qjj RCSB], [http://www.ebi.ac.uk/pdbsum/1qjj PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ASTA_ASTFL ASTA_ASTFL]] This protease prefers to cleave in front of small aliphatic residues (P1'). The presence of Lys or Arg in the P1 and P2 position yields high-turnover substrates. In the P3 position the enzyme prefers Pro > Val > Leu > Ala > Gly. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Astacin]] | [[Category: Astacin]] | ||
[[Category: Astacus astacus]] | [[Category: Astacus astacus]] | ||
| - | [[Category: Bode, W | + | [[Category: Bode, W]] |
| - | [[Category: Grams, F | + | [[Category: Grams, F]] |
| - | [[Category: Stocker, W | + | [[Category: Stocker, W]] |
| - | + | ||
[[Category: Hydrolase-hydrolase inhibitor complex]] | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
[[Category: Metalloproteinase]] | [[Category: Metalloproteinase]] | ||
[[Category: Metzincin]] | [[Category: Metzincin]] | ||
Revision as of 18:15, 24 December 2014
STRUCTURE OF ASTACIN WITH A HYDROXAMIC ACID INHIBITOR
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