1tp5
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tp5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TP5 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tp5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TP5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TP5 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1tp5 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tp5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tp5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tp5 RCSB], [http://www.ebi.ac.uk/pdbsum/1tp5 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Kovari, L | + | [[Category: Kovari, L]] |
| - | [[Category: Martin, P | + | [[Category: Martin, P]] |
| - | [[Category: Paredes, A | + | [[Category: Paredes, A]] |
| - | [[Category: Saro, D | + | [[Category: Saro, D]] |
| - | [[Category: Spaller, M | + | [[Category: Spaller, M]] |
| - | [[Category: Vickrey, J | + | [[Category: Vickrey, J]] |
| - | [[Category: Wawrzak, Z | + | [[Category: Wawrzak, Z]] |
[[Category: Pdz-peptide ligand complex]] | [[Category: Pdz-peptide ligand complex]] | ||
[[Category: Peptide binding protein]] | [[Category: Peptide binding protein]] | ||
Revision as of 18:24, 24 December 2014
Crystal structure of PDZ3 domain of PSD-95 protein complexed with a peptide ligand KKETWV
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