3bjg
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bjg RCSB], [http://www.ebi.ac.uk/pdbsum/3bjg PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bjg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bjg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bjg RCSB], [http://www.ebi.ac.uk/pdbsum/3bjg PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RICI_RICCO RICI_RICCO]] Ricin is highly toxic to animal cells and to a lesser extent to plant cells. The A chain acts as a glycosidase that removes a specific adenine residue from an exposed loop of the 28S rRNA (A4324 in mammals), leading to rRNA breakage. As this loop is involved in elongation factor binding, modified ribosomes are catalytically inactive and unable to support protein synthesis. The A chain can inactivate a few thousand ribosomes per minute, faster than the cell can make new ones. Therefore a single A chain molecule can kill an animal cell. The B chain binds to beta-D-galactopyranoside moieties on cell surface glycoproteins and glycolipids and facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (Lectin activity). | ||
==See Also== | ==See Also== | ||
| Line 14: | Line 16: | ||
[[Category: Ricinus communis]] | [[Category: Ricinus communis]] | ||
[[Category: RRNA N-glycosylase]] | [[Category: RRNA N-glycosylase]] | ||
| - | [[Category: Legler, P M | + | [[Category: Legler, P M]] |
| - | [[Category: Millard, C B | + | [[Category: Millard, C B]] |
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
Revision as of 18:29, 24 December 2014
Structure of Rivax: A Human Ricin Vaccine
| |||||||||||
