2dnu
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2dnu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNU FirstGlance]. <br> | <table><tr><td colspan='2'>[[2dnu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DNU FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dnu RCSB], [http://www.ebi.ac.uk/pdbsum/2dnu PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnu TOPSAN]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2dnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dnu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2dnu RCSB], [http://www.ebi.ac.uk/pdbsum/2dnu PDBsum], [http://www.topsan.org/Proteins/RSGI/2dnu TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SPD2A_HUMAN SPD2A_HUMAN]] Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.<ref>PMID:12615925</ref> <ref>PMID:15710328</ref> <ref>PMID:15710903</ref> <ref>PMID:19755710</ref> <ref>PMID:20609497</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hayashi, F | + | [[Category: Hayashi, F]] |
| - | [[Category: Hirota, H | + | [[Category: Hirota, H]] |
| - | [[Category: Kurosaki, C | + | [[Category: Kurosaki, C]] |
| - | [[Category: Nagashima, T | + | [[Category: Nagashima, T]] |
| - | [[Category: Ohashi, W | + | [[Category: Ohashi, W]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
| - | [[Category: Yoshida, M | + | [[Category: Yoshida, M]] |
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
[[Category: Sh3]] | [[Category: Sh3]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Structural protein]] | [[Category: Structural protein]] | ||
Revision as of 18:36, 24 December 2014
Solution structure of RSGI RUH-061, a SH3 domain from human
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