1yv3

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[[Image:1yv3.gif|left|200px]]<br /><applet load="1yv3" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1yv3.gif|left|200px]]
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caption="1yv3, resolution 2.0&Aring;" />
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'''The structural basis of blebbistatin inhibition and specificity for myosin II'''<br />
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{{Structure
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|PDB= 1yv3 |SIZE=350|CAPTION= <scene name='initialview01'>1yv3</scene>, resolution 2.0&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=VO4:VANADATE+ION'>VO4</scene>, <scene name='pdbligand=ADP:ADENOSINE-5'-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BIT:(-)-1-PHENYL-1,2,3,4-TETRAHYDRO-4-HYDROXYPYRROLO[2,3-B]-7-METHYLQUINOLIN-4-ONE'>BIT</scene> and <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''The structural basis of blebbistatin inhibition and specificity for myosin II'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1YV3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=VO4:'>VO4</scene>, <scene name='pdbligand=ADP:'>ADP</scene>, <scene name='pdbligand=BIT:'>BIT</scene> and <scene name='pdbligand=EDO:'>EDO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YV3 OCA].
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1YV3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YV3 OCA].
==Reference==
==Reference==
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The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15750603 15750603]
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The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15750603 15750603]
[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: myosin-inhibitor complex]]
[[Category: myosin-inhibitor complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:09:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:27:56 2008''

Revision as of 13:27, 20 March 2008

Image:1yv3.gif


PDB ID 1yv3

Drag the structure with the mouse to rotate
, resolution 2.0Å
Ligands: , , , and
Coordinates: save as pdb, mmCIF, xml



The structural basis of blebbistatin inhibition and specificity for myosin II


Overview

Molecular motors play a central role in cytoskeletal-mediated cellular processes and thus present an excellent target for cellular control by pharmacological agents. Yet very few such compounds have been found. We report here the structure of blebbistatin, which inhibits specific myosin isoforms, bound to the motor domain of Dictyostelium discoideum myosin II. This reveals the structural basis for its specificity and provides insight into the development of new agents.

About this Structure

1YV3 is a Single protein structure of sequence from Dictyostelium discoideum. Full crystallographic information is available from OCA.

Reference

The structural basis of blebbistatin inhibition and specificity for myosin II., Allingham JS, Smith R, Rayment I, Nat Struct Mol Biol. 2005 Apr;12(4):378-9. Epub 2005 Mar 6. PMID:15750603

Page seeded by OCA on Thu Mar 20 15:27:56 2008

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