4aea
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4aea]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEA FirstGlance]. <br> | <table><tr><td colspan='2'>[[4aea]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4AEA FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lxh|1lxh]], [[1lxg|1lxg]], [[1ctx|1ctx]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lxh|1lxh]], [[1lxg|1lxg]], [[1ctx|1ctx]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aea RCSB], [http://www.ebi.ac.uk/pdbsum/4aea PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aea RCSB], [http://www.ebi.ac.uk/pdbsum/4aea PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NXL1_NAJKA NXL1_NAJKA]] The monomeric form binds with high affinity to muscular, Torpedo (muscle-type), and neuronal alpha-7 nicotinic acetylcholine receptors (nAChR). Has no effect on alpha-3/beta-2 nAChR. Causes paralysis by preventing acetylcholine binding to the nAChR. Does not show any blockade of the nicotine-evoked release of dopamine and does not affect ACh release. In mice lung cancer, causes reduction of tumor growth.<ref>PMID:18381281</ref> <ref>PMID:6771288</ref> <ref>PMID:6553056</ref> <ref>PMID:2086254</ref> <ref>PMID:9053737</ref> <ref>PMID:9305882</ref> <ref>PMID:9840221</ref> <ref>PMID:10574958</ref> <ref>PMID:18067132</ref> The homodimeric form binds with low affinity to Torpedo (muscle-type) and alpha-7 nAChRs, whereas it acquires the capacity to block alpha-3/beta-2 nAChRs.<ref>PMID:18381281</ref> <ref>PMID:6771288</ref> <ref>PMID:6553056</ref> <ref>PMID:2086254</ref> <ref>PMID:9053737</ref> <ref>PMID:9305882</ref> <ref>PMID:9840221</ref> <ref>PMID:10574958</ref> <ref>PMID:18067132</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Naja kaouthia]] | [[Category: Naja kaouthia]] | ||
| - | [[Category: Andreeva, T V | + | [[Category: Andreeva, T V]] |
| - | [[Category: Bertrand, D | + | [[Category: Bertrand, D]] |
| - | [[Category: Filkin, S Y | + | [[Category: Filkin, S Y]] |
| - | [[Category: Kasheverov, I E | + | [[Category: Kasheverov, I E]] |
| - | [[Category: Osipov, A V | + | [[Category: Osipov, A V]] |
| - | [[Category: Rucktooa, P | + | [[Category: Rucktooa, P]] |
| - | [[Category: Sixma, T K | + | [[Category: Sixma, T K]] |
| - | [[Category: Starkov, V G | + | [[Category: Starkov, V G]] |
| - | [[Category: Tsetlin, V I | + | [[Category: Tsetlin, V I]] |
| - | [[Category: Utkin, Y N | + | [[Category: Utkin, Y N]] |
[[Category: Nicotinic acetylcholine receptor]] | [[Category: Nicotinic acetylcholine receptor]] | ||
[[Category: Three-finger toxin]] | [[Category: Three-finger toxin]] | ||
[[Category: Toxin]] | [[Category: Toxin]] | ||
Revision as of 18:45, 24 December 2014
Dimeric alpha-cobratoxin X-ray structure: Localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors
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