1ywh

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[[Image:1ywh.gif|left|200px]]<br /><applet load="1ywh" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1ywh.gif|left|200px]]
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caption="1ywh, resolution 2.70&Aring;" />
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'''crystal structure of urokinase plasminogen activator receptor'''<br />
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{{Structure
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|PDB= 1ywh |SIZE=350|CAPTION= <scene name='initialview01'>1ywh</scene>, resolution 2.70&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> and <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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|ACTIVITY=
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|GENE= PLAUR, MO3, UPAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''crystal structure of urokinase plasminogen activator receptor'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1YWH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NDG:'>NDG</scene>, <scene name='pdbligand=NAG:'>NAG</scene> and <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWH OCA].
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1YWH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YWH OCA].
==Reference==
==Reference==
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Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide., Llinas P, Le Du MH, Gardsvoll H, Dano K, Ploug M, Gilquin B, Stura EA, Menez A, EMBO J. 2005 May 4;24(9):1655-63. Epub 2005 Apr 7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15861141 15861141]
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Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide., Llinas P, Le Du MH, Gardsvoll H, Dano K, Ploug M, Gilquin B, Stura EA, Menez A, EMBO J. 2005 May 4;24(9):1655-63. Epub 2005 Apr 7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15861141 15861141]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: upar]]
[[Category: upar]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:09:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:28:23 2008''

Revision as of 13:28, 20 March 2008

Image:1ywh.gif


PDB ID 1ywh

Drag the structure with the mouse to rotate
, resolution 2.70Å
Ligands: , and
Gene: PLAUR, MO3, UPAR (Homo sapiens)
Coordinates: save as pdb, mmCIF, xml



crystal structure of urokinase plasminogen activator receptor


Overview

We report the crystal structure of a soluble form of human urokinase-type plasminogen activator receptor (uPAR/CD87), which is expressed at the invasive areas of the tumor-stromal microenvironment in many human cancers. The structure was solved at 2.7 A in association with a competitive peptide inhibitor of the urokinase-type plasminogen activator (uPA)-uPAR interaction. uPAR is composed of three consecutive three-finger domains organized in an almost circular manner, which generates both a deep internal cavity where the peptide binds in a helical conformation, and a large external surface. This knowledge combined with the discovery of a convergent binding motif shared by the antagonist peptide and uPA allowed us to build a model of the human uPA-uPAR complex. This model reveals that the receptor-binding module of uPA engages the uPAR central cavity, thus leaving the external receptor surface accessible for other protein interactions (vitronectin and integrins). By this unique structural assembly, uPAR can orchestrate the fine interplay with the partners that are required to guide uPA-focalized proteolysis on the cell surface and control cell adhesion and migration.

About this Structure

1YWH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide., Llinas P, Le Du MH, Gardsvoll H, Dano K, Ploug M, Gilquin B, Stura EA, Menez A, EMBO J. 2005 May 4;24(9):1655-63. Epub 2005 Apr 7. PMID:15861141

Page seeded by OCA on Thu Mar 20 15:28:23 2008

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