4ani
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_kaustophilus Geobacillus kaustophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ANI FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ani]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_kaustophilus Geobacillus kaustophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ANI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ANI FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v7y|2v7y]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2v7y|2v7y]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ani OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ani RCSB], [http://www.ebi.ac.uk/pdbsum/4ani PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ani FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ani OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ani RCSB], [http://www.ebi.ac.uk/pdbsum/4ani PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRPE_GEOKA GRPE_GEOKA]] Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding (By similarity). [[http://www.uniprot.org/uniprot/DNAK_GEOKA DNAK_GEOKA]] Acts as a chaperone (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 21: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Geobacillus kaustophilus]] | [[Category: Geobacillus kaustophilus]] | ||
| - | [[Category: Chang, Y W | + | [[Category: Chang, Y W]] |
| - | [[Category: Chien, C H | + | [[Category: Chien, C H]] |
| - | [[Category: Hsiao, C D | + | [[Category: Hsiao, C D]] |
| - | [[Category: Naveen, V | + | [[Category: Naveen, V]] |
| - | [[Category: Wu, C C | + | [[Category: Wu, C C]] |
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
[[Category: Chaperone cycle]] | [[Category: Chaperone cycle]] | ||
[[Category: Complementary assay]] | [[Category: Complementary assay]] | ||
Revision as of 18:52, 24 December 2014
Structural basis for the intermolecular communication between DnaK and GrpE in the DnaK chaperone system from Geobacillus kaustophilus HTA426
| |||||||||||
