1uup
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 1UUP is a | + | 1UUP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: ZN1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1UUP OCA]. |
==Reference== | ==Reference== | ||
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[[Category: zinc binding]] | [[Category: zinc binding]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 13:13:42 2007'' |
Revision as of 11:08, 5 November 2007
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CRYSTAL STRUCTURE OF A DIMERIC FORM OF STREPTOCOCCAL PYROGENIC EXOTOXIN A (SPEA1).
Overview
Streptococcal pyrogenic exotoxin A (SpeA1) is a bacterial superantigen, associated with scarlet fever and streptococcal toxic shock syndrome, (STSS). SpeA1 is found in both monomeric and dimeric forms, and previous, work suggested that the dimer results from an intermolecular disulfide, bond between the cysteines at positions 90 of each monomer. Here, we, present the crystal structure of the dimeric form of SpeA1. The toxin, crystallizes in the orthorhombic space group P212121, with two dimers in, the crystallographic asymmetric unit. The final structure has a, crystallographic R-factor of 21.52% for 7248 protein atoms, 136 water, molecules, and 4 zinc atoms (one zinc atom per molecule). The implications, of SpeA1 dimer on MHC class II and T-cell receptor recognition are, discussed.
About this Structure
1UUP is a Single protein structure of sequence from Streptococcus pyogenes with ZN as ligand. Structure known Active Site: ZN1. Full crystallographic information is available from OCA.
Reference
Crystal structure of a dimeric form of streptococcal pyrogenic exotoxin A (SpeA1)., Baker MD, Gendlina I, Collins CM, Acharya KR, Protein Sci. 2004 Sep;13(9):2285-90. Epub 2004 Aug 4. PMID:15295110
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