1qpf
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1qpf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QPF FirstGlance]. <br> | <table><tr><td colspan='2'>[[1qpf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QPF FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=858:C32-O-(1-ETHYL-INDOL-5-YL)ASCOMYCIN'>858</scene>, <scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=858:C32-O-(1-ETHYL-INDOL-5-YL)ASCOMYCIN'>858</scene>, <scene name='pdbligand=B7G:HEPTYL-BETA-D-GLUCOPYRANOSIDE'>B7G</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fkd|1fkd]], [[2fke|2fke]], [[1yat|1yat]], [[1tco|1tco]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1fkd|1fkd]], [[2fke|2fke]], [[1yat|1yat]], [[1tco|1tco]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qpf RCSB], [http://www.ebi.ac.uk/pdbsum/1qpf PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qpf RCSB], [http://www.ebi.ac.uk/pdbsum/1qpf PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FKB1A_HUMAN FKB1A_HUMAN]] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.<ref>PMID:9233797</ref> <ref>PMID:16720724</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Becker, J W | + | [[Category: Becker, J W]] |
| - | [[Category: Rotonda, J | + | [[Category: Rotonda, J]] |
[[Category: Cis-trans isomerase]] | [[Category: Cis-trans isomerase]] | ||
[[Category: Immunophilin-drug complex]] | [[Category: Immunophilin-drug complex]] | ||
[[Category: Isomerase]] | [[Category: Isomerase]] | ||
[[Category: Peptidyl-prolyl isomerase]] | [[Category: Peptidyl-prolyl isomerase]] | ||
Revision as of 19:06, 24 December 2014
FK506 BINDING PROTEIN (12 KDA, HUMAN) COMPLEX WITH L-709,858
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