1z21
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1z21.gif|left|200px]] | + | [[Image:1z21.gif|left|200px]] |
| - | + | ||
| - | '''Crystal structure of the core domain of Yersinia pestis virulence factor YopR''' | + | {{Structure |
| + | |PDB= 1z21 |SIZE=350|CAPTION= <scene name='initialview01'>1z21</scene>, resolution 1.499Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= yscH, lcrP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=632 Yersinia pestis]) | ||
| + | }} | ||
| + | |||
| + | '''Crystal structure of the core domain of Yersinia pestis virulence factor YopR''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1Z21 is a [ | + | 1Z21 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z21 OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR., Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS, Protein Sci. 2005 Jun;14(6):1679-83. PMID:[http:// | + | Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR., Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS, Protein Sci. 2005 Jun;14(6):1679-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15930010 15930010] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Yersinia pestis]] | [[Category: Yersinia pestis]] | ||
| Line 20: | Line 29: | ||
[[Category: plague]] | [[Category: plague]] | ||
[[Category: type iii secretion]] | [[Category: type iii secretion]] | ||
| - | [[Category: yersinia | + | [[Category: yersinia pesti]] |
[[Category: yop]] | [[Category: yop]] | ||
[[Category: yopr]] | [[Category: yopr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:30:20 2008'' |
Revision as of 13:30, 20 March 2008
| |||||||
| , resolution 1.499Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | yscH, lcrP (Yersinia pestis) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of the core domain of Yersinia pestis virulence factor YopR
Overview
Yersinia pestis, the causative agent of the plague, employs a type III secretion system (T3SS) to secrete and translocate virulence factors into to the cytoplasm of mammalian host cells. One of the secreted virulence factors is YopR. Little is known about the function of YopR other than that it is secreted into the extracellular milieu during the early stages of infection and that it contributes to virulence. Hoping to gain some insight into the function of YopR, we determined the crystal structure of its protease-resistant core domain, which consists of residues 38-149 out of 165 amino acids. The core domain is composed of five alpha-helices that display unexpected structural similarity with one domain of YopN, a central regulator of type III secretion in Y. pestis. This finding raises the possibility that YopR may play a role in the regulation of type III secretion.
About this Structure
1Z21 is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.
Reference
Crystal structure of the protease-resistant core domain of Yersinia pestis virulence factor YopR., Schubot FD, Cherry S, Austin BP, Tropea JE, Waugh DS, Protein Sci. 2005 Jun;14(6):1679-83. PMID:15930010
Page seeded by OCA on Thu Mar 20 15:30:20 2008
