1ni1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ni1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NI1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ni1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NI1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NI1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2C5:2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)-+METHOXYMETHYL]-NICOTINONITRILE'>2C5</scene>, <scene name='pdbligand=HFP:ALPHA-HYDROXYFARNESYLPHOSPHONIC+ACID'>HFP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2C5:2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)-+METHOXYMETHYL]-NICOTINONITRILE'>2C5</scene>, <scene name='pdbligand=HFP:ALPHA-HYDROXYFARNESYLPHOSPHONIC+ACID'>HFP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1n9a|1n9a]], [[1n95|1n95]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1n9a|1n9a]], [[1n95|1n95]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FNTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), FNTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FNTA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), FNTB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ni1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ni1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ni1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ni1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ni1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ni1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ni1 RCSB], [http://www.ebi.ac.uk/pdbsum/1ni1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FNTA_RAT FNTA_RAT]] Catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. The alpha subunit is thought to participate in a stable complex with the substrate. The beta subunit binds the peptide substrate. Through RAC1 prenylation and activation may positively regulate neuromuscular junction development downstream of MUSK (By similarity). [[http://www.uniprot.org/uniprot/FNTB_RAT FNTB_RAT]] Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Bauch, J | + | [[Category: Bauch, J]] |
| - | [[Category: Cohen, J | + | [[Category: Cohen, J]] |
| - | [[Category: Gu, W Z | + | [[Category: Gu, W Z]] |
| - | [[Category: Hasvold, L | + | [[Category: Hasvold, L]] |
| - | [[Category: Leonard, N | + | [[Category: Leonard, N]] |
| - | [[Category: Li, Q | + | [[Category: Li, Q]] |
| - | [[Category: Li, T | + | [[Category: Li, T]] |
| - | [[Category: Lin, N H | + | [[Category: Lin, N H]] |
| - | [[Category: Marsh, K | + | [[Category: Marsh, K]] |
| - | [[Category: Rosenberg, S H | + | [[Category: Rosenberg, S H]] |
| - | [[Category: Sham, H L | + | [[Category: Sham, H L]] |
| - | [[Category: Stoll, V | + | [[Category: Stoll, V]] |
| - | [[Category: Tong, Y | + | [[Category: Tong, Y]] |
| - | [[Category: Wang, L | + | [[Category: Wang, L]] |
| - | [[Category: Wang, W | + | [[Category: Wang, W]] |
| - | [[Category: Zhang, H | + | [[Category: Zhang, H]] |
[[Category: Cyanophenyl]] | [[Category: Cyanophenyl]] | ||
[[Category: Ftase]] | [[Category: Ftase]] | ||
[[Category: Prenyltransferase]] | [[Category: Prenyltransferase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 19:15, 24 December 2014
Imidazole and cyanophenyl farnesyl transferase inhibitors
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Categories: Rattus norvegicus | Bauch, J | Cohen, J | Gu, W Z | Hasvold, L | Leonard, N | Li, Q | Li, T | Lin, N H | Marsh, K | Rosenberg, S H | Sham, H L | Stoll, V | Tong, Y | Wang, L | Wang, W | Zhang, H | Cyanophenyl | Ftase | Prenyltransferase | Transferase
