1z3f

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[[Image:1z3f.gif|left|200px]]<br /><applet load="1z3f" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1z3f.gif|left|200px]]
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caption="1z3f, resolution 1.50&Aring;" />
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'''Structure of ellipticine in complex with a 6-bp DNA'''<br />
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{{Structure
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|PDB= 1z3f |SIZE=350|CAPTION= <scene name='initialview01'>1z3f</scene>, resolution 1.50&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=EL:ELLIPTICINE'>EL</scene> and <scene name='pdbligand=CO:COBALT (II) ION'>CO</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of ellipticine in complex with a 6-bp DNA'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Z3F is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=EL:'>EL</scene> and <scene name='pdbligand=CO:'>CO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA].
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1Z3F is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z3F OCA].
==Reference==
==Reference==
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The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs., Canals A, Purciolas M, Aymami J, Coll M, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15983425 15983425]
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The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs., Canals A, Purciolas M, Aymami J, Coll M, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15983425 15983425]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Aymami, J.]]
[[Category: Aymami, J.]]
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[[Category: intercalator]]
[[Category: intercalator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:11:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:30:44 2008''

Revision as of 13:30, 20 March 2008

Image:1z3f.gif


PDB ID 1z3f

Drag the structure with the mouse to rotate
, resolution 1.50Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Structure of ellipticine in complex with a 6-bp DNA


Overview

Ellipticine is a natural plant product that has been found to be a powerful anticancer drug. Although still unclear, its mechanism of action is considered to be mainly based on DNA intercalation and/or the inhibition of topoisomerase II. Many experimental data suggest an intercalation based on stacking interactions along the major base-pair axis, but alternative binding modes have been proposed, in particular for ellipticine derivatives. The 1.5 A resolution structure of ellipticine complexed to a 6 bp oligonucleotide unveils its mode of binding and enables a detailed analysis of the distorting effects of the drug on the DNA.

About this Structure

1Z3F is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

The anticancer agent ellipticine unwinds DNA by intercalative binding in an orientation parallel to base pairs., Canals A, Purciolas M, Aymami J, Coll M, Acta Crystallogr D Biol Crystallogr. 2005 Jul;61(Pt 7):1009-12. Epub 2005, Jun 24. PMID:15983425

Page seeded by OCA on Thu Mar 20 15:30:44 2008

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