4dgb

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[[Image:4dgb.png|left|200px]]
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==TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex==
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<StructureSection load='4dgb' size='340' side='right' caption='[[4dgb]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4dgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DGB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4dga|4dga]], [[4dgc|4dgc]], [[4dgd|4dgd]], [[4dge|4dge]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TRIMCyp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9544 Macaca mulatta])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4dgb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dgb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4dgb RCSB], [http://www.ebi.ac.uk/pdbsum/4dgb PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GAG_HV2RO GAG_HV2RO]] Matrix protein p17 targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane binding signal. Also mediates nuclear localization of the preintegration complex (By similarity). Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex. Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers (By similarity). p6-gag plays a role in budding of the assembled particle by interacting with the host class E VPS proteins TSG101 and PDCD6IP/AIP1.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Rhesus macaque TRIMCyp (RhTC) is a potent primate antiviral host protein that inhibits the replication of diverse HIV viruses. Here we show that it has acquired the ability to target multiple viruses by evolving an active site that interconverts between multiple conformations. Mutations that have relieved active site constraints allow RhTC to dynamically sample conformational space, including radically different conformers that target both HIV-1 and HIV-2 viruses. Introduction of a reversible constraint into RhTC allows specificity to be switched between a single conformation specific for HIV-1 and a dynamic ensemble that targets multiple viruses. These results show that conformational diversity can be used to expand the target diversity of innate immune receptors by supplementing their limited genetic variability with variability in protein structure.
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Diverse HIV viruses are targeted by a conformationally dynamic antiviral.,Caines ME, Bichel K, Price AJ, McEwan WA, Towers GJ, Willett BJ, Freund SM, James LC Nat Struct Mol Biol. 2012 Mar 11. doi: 10.1038/nsmb.2253. PMID:22407016<ref>PMID:22407016</ref>
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{{STRUCTURE_4dgb| PDB=4dgb | SCENE= }}
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===TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
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*[[Cyclophilin|Cyclophilin]]
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The line below this paragraph, {{ABSTRACT_PUBMED_22407016}}, adds the Publication Abstract to the page
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== References ==
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(as it appears on PubMed at http://www.pubmed.gov), where 22407016 is the PubMed ID number.
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<references/>
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__TOC__
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{{ABSTRACT_PUBMED_22407016}}
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</StructureSection>
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==About this Structure==
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[[4dgb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DGB OCA].
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==Reference==
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<ref group="xtra">PMID:022407016</ref><references group="xtra"/>
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[[Category: Macaca mulatta]]
[[Category: Macaca mulatta]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Peptidylprolyl isomerase]]
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[[Category: Bichel, K.]]
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[[Category: Bichel, K]]
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[[Category: Caines, M E.C.]]
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[[Category: Caines, M E.C]]
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[[Category: James, L C.]]
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[[Category: James, L C]]
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[[Category: McEwan, W A.]]
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[[Category: McEwan, W A]]
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[[Category: Price, A J.]]
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[[Category: Price, A J]]
[[Category: Anti-viral protein]]
[[Category: Anti-viral protein]]
[[Category: Isomerase-viral protein complex]]
[[Category: Isomerase-viral protein complex]]

Revision as of 19:19, 24 December 2014

TRIMCyp cyclophilin domain from Macaca mulatta: HIV-2 CA cyclophilin-binding loop complex

4dgb, resolution 1.70Å

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