4a54
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4a54]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A54 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A54 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4a54]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A54 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A54 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a6t|2a6t]], [[4a53|4a53]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2a6t|2a6t]], [[4a53|4a53]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a54 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a54 RCSB], [http://www.ebi.ac.uk/pdbsum/4a54 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a54 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a54 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a54 RCSB], [http://www.ebi.ac.uk/pdbsum/4a54 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DCP2_SCHPO DCP2_SCHPO]] Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body.<ref>PMID:15671491</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Schizosaccharomyces pombe]] | [[Category: Schizosaccharomyces pombe]] | ||
| - | [[Category: Braun, J E | + | [[Category: Braun, J E]] |
| - | [[Category: Fromm, S A | + | [[Category: Fromm, S A]] |
| - | [[Category: Hoffmann, N A | + | [[Category: Hoffmann, N A]] |
| - | [[Category: Izaurralde, E | + | [[Category: Izaurralde, E]] |
| - | [[Category: Kamenz, J | + | [[Category: Kamenz, J]] |
| - | [[Category: Sprangers, R | + | [[Category: Sprangers, R]] |
| - | [[Category: Truffault, V | + | [[Category: Truffault, V]] |
[[Category: Rna binding protein-hydrolase complex]] | [[Category: Rna binding protein-hydrolase complex]] | ||
Revision as of 19:23, 24 December 2014
Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6
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