1z56
From Proteopedia
| Line 1: | Line 1: | ||
| - | [[Image:1z56.gif|left|200px]] | + | [[Image:1z56.gif|left|200px]] |
| - | + | ||
| - | '''Co-Crystal Structure of Lif1p-Lig4p''' | + | {{Structure |
| + | |PDB= 1z56 |SIZE=350|CAPTION= <scene name='initialview01'>1z56</scene>, resolution 3.92Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/DNA_ligase_(ATP) DNA ligase (ATP)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.5.1.1 6.5.1.1] | ||
| + | |GENE= LIF1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), DNL4, LIG4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | }} | ||
| + | |||
| + | '''Co-Crystal Structure of Lif1p-Lig4p''' | ||
| + | |||
==Overview== | ==Overview== | ||
| Line 7: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1Z56 is a [ | + | 1Z56 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z56 OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode., Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL, DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:[http:// | + | Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode., Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL, DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16388993 16388993] |
[[Category: DNA ligase (ATP)]] | [[Category: DNA ligase (ATP)]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| Line 29: | Line 38: | ||
[[Category: xrcc4]] | [[Category: xrcc4]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:31:18 2008'' |
Revision as of 13:31, 20 March 2008
| |||||||
| , resolution 3.92Å | |||||||
|---|---|---|---|---|---|---|---|
| Gene: | LIF1 (Saccharomyces cerevisiae), DNL4, LIG4 (Saccharomyces cerevisiae) | ||||||
| Activity: | DNA ligase (ATP), with EC number 6.5.1.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Co-Crystal Structure of Lif1p-Lig4p
Overview
DNA ligase IV catalyses the final ligation step in the non-homologous end-joining (NHEJ) DNA repair pathway and requires interaction of the ligase with the Xrcc4 'genome-guardian', an essential NHEJ factor. Here we report the 3.9 A crystal structure of the Saccharomyces cerevisiae Xrcc4 ortholog ligase interacting factor 1 (Lif1p) complexed with the C-terminal BRCT domains of DNA ligase IV (Lig4p). The structure reveals a novel mode of protein recognition by a tandem BRCT repeat, and in addition provides a molecular basis for a human LIG4 syndrome clinical condition.
About this Structure
1Z56 is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode., Dore AS, Furnham N, Davies OR, Sibanda BL, Chirgadze DY, Jackson SP, Pellegrini L, Blundell TL, DNA Repair (Amst). 2006 Mar 7;5(3):362-8. Epub 2006 Jan 18. PMID:16388993
Page seeded by OCA on Thu Mar 20 15:31:18 2008
