1z58

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[[Image:1z58.gif|left|200px]]<br /><applet load="1z58" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1z58.gif|left|200px]]
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caption="1z58, resolution 3.8&Aring;" />
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'''Crystal structure of a complex of the ribosome large subunit with rapamycin'''<br />
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{{Structure
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|PDB= 1z58 |SIZE=350|CAPTION= <scene name='initialview01'>1z58</scene>, resolution 3.8&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=RAP:RAPAMYCIN IMMUNOSUPPRESSANT DRUG'>RAP</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure of a complex of the ribosome large subunit with rapamycin'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Z58 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] with <scene name='pdbligand=RAP:'>RAP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA].
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1Z58 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z58 OCA].
==Reference==
==Reference==
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A crevice adjoining the ribosome tunnel: hints for cotranslational folding., Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A, FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15943964 15943964]
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A crevice adjoining the ribosome tunnel: hints for cotranslational folding., Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A, FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15943964 15943964]
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: tunnel]]
[[Category: tunnel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:31:22 2008''

Revision as of 13:31, 20 March 2008

Image:1z58.gif


PDB ID 1z58

Drag the structure with the mouse to rotate
, resolution 3.8Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Crystal structure of a complex of the ribosome large subunit with rapamycin


Overview

RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.

About this Structure

1Z58 is a Single protein structure of sequence from Deinococcus radiodurans. Full crystallographic information is available from OCA.

Reference

A crevice adjoining the ribosome tunnel: hints for cotranslational folding., Amit M, Berisio R, Baram D, Harms J, Bashan A, Yonath A, FEBS Lett. 2005 Jun 13;579(15):3207-13. Epub 2005 Mar 23. PMID:15943964

Page seeded by OCA on Thu Mar 20 15:31:22 2008

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