3w1a
From Proteopedia
(Difference between revisions)
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| - | + | ==Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives== | |
| - | + | <StructureSection load='3w1a' size='340' side='right' caption='[[3w1a]], [[Resolution|resolution]] 1.42Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | ==Function== | + | <table><tr><td colspan='2'>[[3w1a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycc Trycc]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W1A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W1A FirstGlance]. <br> |
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=FOT:5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC+ACID'>FOT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NCO:COBALT+HEXAMMINE(III)'>NCO</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DHOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=353153 TRYCC])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_oxidase_(fumarate) Dihydroorotate oxidase (fumarate)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.98.1 1.3.98.1] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w1a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w1a RCSB], [http://www.ebi.ac.uk/pdbsum/3w1a PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
[[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. | [[http://www.uniprot.org/uniprot/PYRD_TRYCC PYRD_TRYCC]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]] |
| - | [[Category: Aoki, T | + | __TOC__ |
| - | [[Category: Balogun, E O | + | </StructureSection> |
| - | [[Category: Harada, S | + | [[Category: Trycc]] |
| - | [[Category: Honma, T | + | [[Category: Aoki, T]] |
| - | [[Category: Iida, M | + | [[Category: Balogun, E O]] |
| - | [[Category: Inaoka, D K | + | [[Category: Harada, S]] |
| - | [[Category: Inoue, M | + | [[Category: Honma, T]] |
| - | [[Category: Kita, K | + | [[Category: Iida, M]] |
| - | [[Category: Lee, N | + | [[Category: Inaoka, D K]] |
| - | [[Category: Matsuoka, S | + | [[Category: Inoue, M]] |
| - | [[Category: Nara, T | + | [[Category: Kita, K]] |
| - | [[Category: Sakamoto, K | + | [[Category: Lee, N]] |
| - | [[Category: Shiba, T | + | [[Category: Matsuoka, S]] |
| - | [[Category: Suzuki, S | + | [[Category: Nara, T]] |
| - | [[Category: Tabuchi, T | + | [[Category: Sakamoto, K]] |
| - | [[Category: Tanaka, A | + | [[Category: Shiba, T]] |
| + | [[Category: Suzuki, S]] | ||
| + | [[Category: Tabuchi, T]] | ||
| + | [[Category: Tanaka, A]] | ||
[[Category: Cytosol]] | [[Category: Cytosol]] | ||
[[Category: Dihydroorotate/orotate binding]] | [[Category: Dihydroorotate/orotate binding]] | ||
[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Rossmann fold]] | [[Category: Rossmann fold]] | ||
Revision as of 19:27, 24 December 2014
Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with 5-halogenated orotate derivatives
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Categories: Trycc | Aoki, T | Balogun, E O | Harada, S | Honma, T | Iida, M | Inaoka, D K | Inoue, M | Kita, K | Lee, N | Matsuoka, S | Nara, T | Sakamoto, K | Shiba, T | Suzuki, S | Tabuchi, T | Tanaka, A | Cytosol | Dihydroorotate/orotate binding | Oxidoreductase | Rossmann fold
