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1z6o
From Proteopedia
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| - | [[Image:1z6o.gif|left|200px]] | + | [[Image:1z6o.gif|left|200px]] |
| - | + | ||
| - | '''Crystal Structure of Trichoplusia ni secreted ferritin''' | + | {{Structure |
| + | |PDB= 1z6o |SIZE=350|CAPTION= <scene name='initialview01'>1z6o</scene>, resolution 1.91Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene> and <scene name='pdbligand=CA:CALCIUM ION'>CA</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
| + | |||
| + | '''Crystal Structure of Trichoplusia ni secreted ferritin''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1Z6O is a [ | + | 1Z6O is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Trichoplusia_ni Trichoplusia ni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z6O OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains., Hamburger AE, West AP Jr, Hamburger ZA, Hamburger P, Bjorkman PJ, J Mol Biol. 2005 Jun 10;349(3):558-69. Epub 2005 Apr 12. PMID:[http:// | + | Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains., Hamburger AE, West AP Jr, Hamburger ZA, Hamburger P, Bjorkman PJ, J Mol Biol. 2005 Jun 10;349(3):558-69. Epub 2005 Apr 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15896348 15896348] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Trichoplusia ni]] | [[Category: Trichoplusia ni]] | ||
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[[Category: metal binding protein]] | [[Category: metal binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:31:47 2008'' |
Revision as of 13:31, 20 March 2008
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| , resolution 1.91Å | |||||||
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| Ligands: | and | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Trichoplusia ni secreted ferritin
Overview
Ferritins are iron storage proteins made of 24 subunits forming a hollow spherical shell. Vertebrate ferritins contain varying ratios of heavy (H) and light (L) chains; however, known ferritin structures include only one type of chain and have octahedral symmetry. Here, we report the 1.9A structure of a secreted insect ferritin from Trichoplusia ni, which reveals equal numbers of H and L chains arranged with tetrahedral symmetry. The H/L-chain interface includes complementary features responsible for ordered assembly of the subunits. The H chain contains a ferroxidase active site resembling that of vertebrate H chains with an endogenous, bound iron atom. The L chain lacks the residues that form a putative iron core nucleation site in vertebrate L chains. Instead, a possible nucleation site is observed at the L chain 3-fold pore. The structure also reveals inter- and intrasubunit disulfide bonds, mostly in the extended N-terminal regions unique to insect ferritins. The symmetrical arrangement of H and L chains and the disulfide crosslinks reflect adaptations of insect ferritin to its role as a secreted protein.
About this Structure
1Z6O is a Protein complex structure of sequences from Trichoplusia ni. Full crystallographic information is available from OCA.
Reference
Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains., Hamburger AE, West AP Jr, Hamburger ZA, Hamburger P, Bjorkman PJ, J Mol Biol. 2005 Jun 10;349(3):558-69. Epub 2005 Apr 12. PMID:15896348
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