4jbm

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{{STRUCTURE_4jbm| PDB=4jbm | SCENE= }}
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==Structure of murine DNA binding protein bound with ds DNA==
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===Structure of murine DNA binding protein bound with ds DNA===
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<StructureSection load='4jbm' size='340' side='right' caption='[[4jbm]], [[Resolution|resolution]] 2.22&Aring;' scene=''>
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== Structural highlights ==
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==Function==
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<table><tr><td colspan='2'>[[4jbm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JBM FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jbj|4jbj]], [[4jbk|4jbk]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Aim2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jbm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jbm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jbm RCSB], [http://www.ebi.ac.uk/pdbsum/4jbm PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/AIM2_MOUSE AIM2_MOUSE]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.<ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:19131592</ref> <ref>PMID:20417169</ref> <ref>PMID:20351693</ref> <ref>PMID:20351692</ref> <ref>PMID:20457908</ref> <ref>PMID:22555457</ref> <ref>PMID:21902795</ref>
[[http://www.uniprot.org/uniprot/AIM2_MOUSE AIM2_MOUSE]] Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8.<ref>PMID:19158676</ref> <ref>PMID:19158675</ref> <ref>PMID:19131592</ref> <ref>PMID:20417169</ref> <ref>PMID:20351693</ref> <ref>PMID:20351692</ref> <ref>PMID:20457908</ref> <ref>PMID:22555457</ref> <ref>PMID:21902795</ref>
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== References ==
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==About this Structure==
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<references/>
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[[4jbm]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBM OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:023567559</ref><references group="xtra"/><references/>
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Cheng, G.]]
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[[Category: Cheng, G]]
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[[Category: Crowley, C.]]
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[[Category: Crowley, C]]
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[[Category: Ding, W.]]
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[[Category: Ding, W]]
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[[Category: Hung, L W.]]
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[[Category: Hung, L W]]
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[[Category: Liu, Z J.]]
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[[Category: Liu, Z J]]
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[[Category: Ni, X.]]
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[[Category: Ni, X]]
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[[Category: Ru, H.]]
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[[Category: Ru, H]]
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[[Category: Shaw, N.]]
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[[Category: Shaw, N]]
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[[Category: Zhao, L.]]
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[[Category: Zhao, L]]
[[Category: Dna]]
[[Category: Dna]]
[[Category: Dna binding protein-dna complex]]
[[Category: Dna binding protein-dna complex]]
[[Category: Ob fold]]
[[Category: Ob fold]]

Revision as of 19:34, 24 December 2014

Structure of murine DNA binding protein bound with ds DNA

4jbm, resolution 2.22Å

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