1z7s

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[[Image:1z7s.gif|left|200px]]<br /><applet load="1z7s" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1z7s.gif|left|200px]]
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caption="1z7s, resolution 3.20&Aring;" />
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'''The crystal structure of coxsackievirus A21'''<br />
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{{Structure
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|PDB= 1z7s |SIZE=350|CAPTION= <scene name='initialview01'>1z7s</scene>, resolution 3.20&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene> and <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''The crystal structure of coxsackievirus A21'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1Z7S is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=MYR:'>MYR</scene> and <scene name='pdbligand=G:'>G</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7S OCA].
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1Z7S is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_coxsackievirus_a21 Human coxsackievirus a21]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z7S OCA].
==Reference==
==Reference==
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The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16004874 16004874]
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The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16004874 16004874]
[[Category: Human coxsackievirus a21]]
[[Category: Human coxsackievirus a21]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: viral protein]]
[[Category: viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:12:56 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:32:11 2008''

Revision as of 13:32, 20 March 2008

Image:1z7s.gif


PDB ID 1z7s

Drag the structure with the mouse to rotate
, resolution 3.20Å
Ligands: , and
Coordinates: save as pdb, mmCIF, xml



The crystal structure of coxsackievirus A21


Overview

CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.

About this Structure

1Z7S is a Protein complex structure of sequences from Human coxsackievirus a21. Full crystallographic information is available from OCA.

Reference

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874

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