1ngm
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ngm]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NGM FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ngm]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NGM FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ngm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ngm RCSB], [http://www.ebi.ac.uk/pdbsum/1ngm PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ngm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ngm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ngm RCSB], [http://www.ebi.ac.uk/pdbsum/1ngm PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TF3B_YEAST TF3B_YEAST]] General activator of RNA polymerase III transcription. Interacts with TBP. Binds to Pol III subunit C34 and to the TAU135 component of TFIIIC. [[http://www.uniprot.org/uniprot/TBP_YEAST TBP_YEAST]] General transcription factor that functions at the core of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.<ref>PMID:9618449</ref> <ref>PMID:12138208</ref> <ref>PMID:12516863</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Geiduschek, E P | + | [[Category: Geiduschek, E P]] |
| - | [[Category: Juo, Z S | + | [[Category: Juo, Z S]] |
| - | [[Category: Kassavetis, G A | + | [[Category: Kassavetis, G A]] |
| - | [[Category: Sigler, P B | + | [[Category: Sigler, P B]] |
| - | [[Category: Wang, J | + | [[Category: Wang, J]] |
[[Category: Brf]] | [[Category: Brf]] | ||
[[Category: Brf1]] | [[Category: Brf1]] | ||
Revision as of 20:00, 24 December 2014
Crystal structure of a yeast Brf1-TBP-DNA ternary complex
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