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1iyw

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1iyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IYW FirstGlance]. <br>
<table><tr><td colspan='2'>[[1iyw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IYW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IYW FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gax|1gax]], [[1ivs|1ivs]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gax|1gax]], [[1ivs|1ivs]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Valine--tRNA_ligase Valine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.9 6.1.1.9] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Valine--tRNA_ligase Valine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.9 6.1.1.9] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iyw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iyw RCSB], [http://www.ebi.ac.uk/pdbsum/1iyw PDBsum], [http://www.topsan.org/Proteins/RSGI/1iyw TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1iyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1iyw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1iyw RCSB], [http://www.ebi.ac.uk/pdbsum/1iyw PDBsum], [http://www.topsan.org/Proteins/RSGI/1iyw TOPSAN]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SYV_THETH SYV_THETH]] Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.[HAMAP-Rule:MF_02004]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
[[Category: Valine--tRNA ligase]]
[[Category: Valine--tRNA ligase]]
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[[Category: Fukai, S.]]
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[[Category: Fukai, S]]
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[[Category: Nureki, O.]]
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[[Category: Nureki, O]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Structural genomic]]
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[[Category: Sekine, S.]]
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[[Category: Sekine, S]]
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[[Category: Shimada, A.]]
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[[Category: Shimada, A]]
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[[Category: Vassylyev, D G.]]
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[[Category: Vassylyev, D G]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama, S]]
[[Category: Ligase]]
[[Category: Ligase]]
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[[Category: Riken structural genomics/proteomics initiative]]
 
[[Category: Rossmann fold]]
[[Category: Rossmann fold]]
[[Category: Rsgi]]
[[Category: Rsgi]]
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[[Category: Structural genomic]]
 

Revision as of 20:01, 24 December 2014

Preliminary Structure of Thermus thermophilus Ligand-Free Valyl-tRNA Synthetase

1iyw, resolution 4.00Å

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