1zea

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[[Image:1zea.gif|left|200px]]<br /><applet load="1zea" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1zea.gif|left|200px]]
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caption="1zea, resolution 1.78&Aring;" />
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'''Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide'''<br />
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{{Structure
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|PDB= 1zea |SIZE=350|CAPTION= <scene name='initialview01'>1zea</scene>, resolution 1.78&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CIT:CITRIC ACID'>CIT</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ZEA is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CIT:'>CIT</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZEA OCA].
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1ZEA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZEA OCA].
==Reference==
==Reference==
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Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition., Scheerer P, Kramer A, Otte L, Seifert M, Wessner H, Scholz C, Krauss N, Schneider-Mergener J, Hohne W, J Mol Recognit. 2007 Jul-Aug;20(4):263-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17712773 17712773]
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Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition., Scheerer P, Kramer A, Otte L, Seifert M, Wessner H, Scholz C, Krauss N, Schneider-Mergener J, Hohne W, J Mol Recognit. 2007 Jul-Aug;20(4):263-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17712773 17712773]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: substitution matrix]]
[[Category: substitution matrix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:14:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:34:23 2008''

Revision as of 13:34, 20 March 2008

Image:1zea.gif


PDB ID 1zea

Drag the structure with the mouse to rotate
, resolution 1.78Å
Ligands:
Coordinates: save as pdb, mmCIF, xml



Structure of the anti-cholera toxin antibody Fab fragment TE33 in complex with a D-peptide


Overview

The structure of a complex of the anti-cholera toxin antibody TE33 Fab (fragment antibody) with the D-peptide vpGsqhyds was solved to 1.78 A resolution. The D-peptide was derived from the linear L-peptide epitope VPGSQHIDS by a stepwise transformation. Despite the very similar amino acid sequence-the only difference is a tyrosine residue in position 7-there are marked differences in the individual positions with respect to their contribution to the peptide overall affinity as ascertained by a complete substitutional analysis. This is reflected by the X-ray structure of the TE33 Fab/D-peptide complex where there is an inverted orientation of the D-peptide as compared with the known structure of a corresponding complex containing the epitope L-peptide, with the side chains establishing different contacts within the binding site of TE33. The D- and L-peptide affinities are comparable and the surface areas buried by complex formation are almost the same. Thus the antibody TE33 provides a typical example for polyspecific binding behavior of IgG family antibodies.

About this Structure

1ZEA is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition., Scheerer P, Kramer A, Otte L, Seifert M, Wessner H, Scholz C, Krauss N, Schneider-Mergener J, Hohne W, J Mol Recognit. 2007 Jul-Aug;20(4):263-74. PMID:17712773

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