1xbo

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xbo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XBO FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xbo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XBO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IX1:5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC+ACID'>IX1</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IX1:5-(3-{3-[3-HYDROXY-2-(METHOXYCARBONYL)PHENOXY]PROPENYL}PHENYL)-4-(HYDROXYMETHYL)ISOXAZOLE-3-CARBOXYLIC+ACID'>IX1</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nl9|1nl9]], [[1nny|1nny]], [[1no6|1no6]], [[1nzz|1nzz]], [[1ony|1ony]], [[1onz|1onz]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1nl9|1nl9]], [[1nny|1nny]], [[1no6|1no6]], [[1nzz|1nzz]], [[1ony|1ony]], [[1onz|1onz]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1, PTP1B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xbo RCSB], [http://www.ebi.ac.uk/pdbsum/1xbo PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xbo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1xbo RCSB], [http://www.ebi.ac.uk/pdbsum/1xbo PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Protein-tyrosine-phosphatase]]
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[[Category: Abad-Zapatero, C.]]
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[[Category: Abad-Zapatero, C]]
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[[Category: Ballaron, S J.]]
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[[Category: Ballaron, S J]]
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[[Category: Hajduk, P J.]]
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[[Category: Hajduk, P J]]
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[[Category: Hassach, D L.]]
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[[Category: Hassach, D L]]
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[[Category: Hutchins, C W.]]
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[[Category: Hutchins, C W]]
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[[Category: Jirousek, M R.]]
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[[Category: Jirousek, M R]]
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[[Category: Kaszubska, W.]]
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[[Category: Kaszubska, W]]
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[[Category: Liu, G.]]
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[[Category: Liu, G]]
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[[Category: Lubben, T H.]]
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[[Category: Lubben, T H]]
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[[Category: Pei, Z.]]
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[[Category: Pei, Z]]
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[[Category: Rondinone, C M.]]
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[[Category: Rondinone, C M]]
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[[Category: Serby, M.]]
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[[Category: Serby, M]]
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[[Category: Szczepankiewicz, B G.]]
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[[Category: Szczepankiewicz, B G]]
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[[Category: Trevillyan, J M.]]
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[[Category: Trevillyan, J M]]
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[[Category: Xin, Z.]]
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[[Category: Xin, Z]]
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[[Category: Zhao, H.]]
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[[Category: Zhao, H]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Isoxazole carboxylic acid]]
[[Category: Isoxazole carboxylic acid]]
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Ptp1b]]
[[Category: Ptp1b]]

Revision as of 20:03, 24 December 2014

PTP1B complexed with Isoxazole Carboxylic Acid

1xbo, resolution 2.50Å

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OCA

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