1tge
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1tge]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2_puerto_rico/pr159-s1/1969 Dengue virus 2 puerto rico/pr159-s1/1969]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TGE FirstGlance]. <br> | <table><tr><td colspan='2'>[[1tge]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2_puerto_rico/pr159-s1/1969 Dengue virus 2 puerto rico/pr159-s1/1969]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TGE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TGE FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tg8|1tg8]], [[1thd|1thd]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1tg8|1tg8]], [[1thd|1thd]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tge OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tge RCSB], [http://www.ebi.ac.uk/pdbsum/1tge PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tge FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tge OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1tge RCSB], [http://www.ebi.ac.uk/pdbsum/1tge PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/POLG_DEN2T POLG_DEN2T]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity). Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome (By similarity). Non-structural protein 2A may be involved viral RNA replication and capsid assembly (Potential). Non-structural protein 2B is a required cofactor for the serine protease function of NS3 (By similarity). Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Dengue virus 2 puerto rico/pr159-s1/1969]] | [[Category: Dengue virus 2 puerto rico/pr159-s1/1969]] | ||
| - | [[Category: Baker, T S | + | [[Category: Baker, T S]] |
| - | [[Category: Clements, D | + | [[Category: Clements, D]] |
| - | [[Category: Kuhn, R J | + | [[Category: Kuhn, R J]] |
| - | [[Category: Ogata, S | + | [[Category: Ogata, S]] |
| - | [[Category: Rossmann, M G | + | [[Category: Rossmann, M G]] |
| - | [[Category: Strauss, J H | + | [[Category: Strauss, J H]] |
| - | [[Category: Zhang, W | + | [[Category: Zhang, W]] |
| - | [[Category: Zhang, Y | + | [[Category: Zhang, Y]] |
[[Category: Dengue immature virus]] | [[Category: Dengue immature virus]] | ||
[[Category: Flavivirus]] | [[Category: Flavivirus]] | ||
Revision as of 20:18, 24 December 2014
The structure of immature Dengue virus at 12.5 angstrom
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