1ziw
From Proteopedia
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| - | [[Image:1ziw.gif|left|200px]] | + | [[Image:1ziw.gif|left|200px]] |
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| - | '''Human Toll-like Receptor 3 extracellular domain structure''' | + | {{Structure |
| + | |PDB= 1ziw |SIZE=350|CAPTION= <scene name='initialview01'>1ziw</scene>, resolution 2.10Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= TLR3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | }} | ||
| + | |||
| + | '''Human Toll-like Receptor 3 extracellular domain structure''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZIW is a [ | + | 1ZIW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZIW OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of human toll-like receptor 3 (TLR3) ectodomain., Choe J, Kelker MS, Wilson IA, Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:[http:// | + | Crystal structure of human toll-like receptor 3 (TLR3) ectodomain., Choe J, Kelker MS, Wilson IA, Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15961631 15961631] |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: innate immunity]] | [[Category: innate immunity]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:36:01 2008'' |
Revision as of 13:36, 20 March 2008
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| , resolution 2.10Å | |||||||
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| Ligands: | , , and | ||||||
| Gene: | TLR3 (Homo sapiens) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Human Toll-like Receptor 3 extracellular domain structure
Overview
Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA.
About this Structure
1ZIW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of human toll-like receptor 3 (TLR3) ectodomain., Choe J, Kelker MS, Wilson IA, Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:15961631
Page seeded by OCA on Thu Mar 20 15:36:01 2008
Categories: Homo sapiens | Single protein | Choe, J. | Wilson, I A. | GOL | NAG | NDG | SO4 | Innate immunity
