4tkf

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tkf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tkf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tkf RCSB], [http://www.ebi.ac.uk/pdbsum/4tkf PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TNKS2_HUMAN TNKS2_HUMAN]] Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles.<ref>PMID:11802774</ref> <ref>PMID:11739745</ref> <ref>PMID:19759537</ref> <ref>PMID:21478859</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Battaile, K P.]]
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[[Category: Battaile, K P]]
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[[Category: Beletskaya, I.]]
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[[Category: Beletskaya, I]]
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[[Category: Chirgadze, N Y.]]
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[[Category: Chirgadze, N Y]]
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[[Category: Gebremeskel, S.]]
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[[Category: Gebremeskel, S]]
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[[Category: Gordon, R.]]
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[[Category: Gordon, R]]
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[[Category: Lam, R.]]
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[[Category: Lam, R]]
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[[Category: Pai, E F.]]
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[[Category: Pai, E F]]
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[[Category: Qiu, W.]]
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[[Category: Qiu, W]]
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[[Category: Romanov, V.]]
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[[Category: Romanov, V]]
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[[Category: Thompson, C.]]
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[[Category: Thompson, C]]
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[[Category: Vodsedalek, J.]]
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[[Category: Vodsedalek, J]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 20:23, 24 December 2014

Crystal Structure of human Tankyrase 2 in complex with IWR-1.

4tkf, resolution 2.60Å

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