4aa2
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aa2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aa2 RCSB], [http://www.ebi.ac.uk/pdbsum/4aa2 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4aa2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4aa2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4aa2 RCSB], [http://www.ebi.ac.uk/pdbsum/4aa2 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACE_DROME ACE_DROME]] May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.<ref>PMID:12591244</ref> [[http://www.uniprot.org/uniprot/BNP_GLOBL BNP_GLOBL]] Blomhotin: inhibits the rabbit lung angiotensin-converting enzyme (ACE) with an IC(50) of 15 uM. Bradykinin-potentiating peptide A: causes no contraction of the rat gastric fundus smooth muscle even at high concentrations. Bradykinin-potentiating peptide B: inhibits the activity of the angiotensin-converting enzyme (ACE) by a preferential interaction with its C-domain. Also potentiates the hypotensive effects of bradykinin. Inhibits the rabbit lung ACE with an IC(50) of 1.1 uM. Bradykinin-potentiating peptide C: inhibits the activity of the angiotensin-converting enzyme (ACE) by interacting with the same potency to its C- and N-domains (PubMed:11994001). Inhibits the rabbit lung angiotensin-converting enzyme (ACE) with an IC(50) of 7.1 uM.<ref>PMID:11994001</ref> Leu3-blomhotin: inhibits the rabbit lung angiotensin-converting enzyme (ACE) with an IC(50) of 46 uM. Synthetic Leu3-blomhotin contracts the rat gastric fundus smooth muscle in a rapid and transient manner. Bradykinin-potentiating peptide Ahb1: potentiates the bradykinin in vivo. Bradykinin-potentiating peptide Ahb2: does not show any bradykinin-potentiating effects. C-type natriuretic peptide: exhibits hypotensive and vasodepressor activity. Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity). | ||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Revision as of 20:28, 24 December 2014
Crystal structure of ANCE in complex with bradykinin potentiating peptide b
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