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1u9a
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1u9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9A FirstGlance]. <br> | <table><tr><td colspan='2'>[[1u9a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1U9A FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u9a RCSB], [http://www.ebi.ac.uk/pdbsum/1u9a PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1u9a RCSB], [http://www.ebi.ac.uk/pdbsum/1u9a PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UBC9_MOUSE UBC9_MOUSE]] Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly-SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity).<ref>PMID:16326389</ref> <ref>PMID:17187077</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Ubiquitin--protein ligase]] | [[Category: Ubiquitin--protein ligase]] | ||
| - | [[Category: Bernards, R | + | [[Category: Bernards, R]] |
| - | [[Category: Hateboer, G | + | [[Category: Hateboer, G]] |
| - | [[Category: Perrakis, A | + | [[Category: Perrakis, A]] |
| - | [[Category: Sixma, T K | + | [[Category: Sixma, T K]] |
| - | [[Category: Tong, H | + | [[Category: Tong, H]] |
[[Category: Cell cycle control]] | [[Category: Cell cycle control]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
[[Category: Ubiquitin-conjugating enzyme]] | [[Category: Ubiquitin-conjugating enzyme]] | ||
[[Category: Ubiquitin-directed proteolysis]] | [[Category: Ubiquitin-directed proteolysis]] | ||
Revision as of 20:31, 24 December 2014
HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9
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