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1zo0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1zo0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZO0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1zo0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZO0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ZO0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zo0 RCSB], [http://www.ebi.ac.uk/pdbsum/1zo0 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zo0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zo0 RCSB], [http://www.ebi.ac.uk/pdbsum/1zo0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/OAZ1_RAT OAZ1_RAT]] Binds to, and destabilizes, ornithine decarboxylase which is then degraded. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity).<ref>PMID:8166639</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Antizyme Inhibitor|Antizyme Inhibitor]] | *[[Antizyme Inhibitor|Antizyme Inhibitor]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Hackert, M L | + | [[Category: Hackert, M L]] |
| - | [[Category: Hoffman, D W | + | [[Category: Hoffman, D W]] |
[[Category: Antizyme]] | [[Category: Antizyme]] | ||
[[Category: Lyase inhibitor]] | [[Category: Lyase inhibitor]] | ||
[[Category: Ornithine decarboxylase inhibitor]] | [[Category: Ornithine decarboxylase inhibitor]] | ||
Revision as of 20:36, 24 December 2014
NMR structure of antizyme isoform 1 from rat
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