1zmv
From Proteopedia
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| - | [[Image:1zmv.gif|left|200px]] | + | [[Image:1zmv.gif|left|200px]] |
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| - | '''Catalytic and ubiqutin-associated domains of MARK2/PAR-1: K82R mutant''' | + | {{Structure |
| + | |PDB= 1zmv |SIZE=350|CAPTION= <scene name='initialview01'>1zmv</scene>, resolution 3.105Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= [http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] | ||
| + | |GENE= MARK2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
| + | }} | ||
| + | |||
| + | '''Catalytic and ubiqutin-associated domains of MARK2/PAR-1: K82R mutant''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZMV is a [ | + | 1ZMV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZMV OCA]. |
==Reference== | ==Reference== | ||
| - | Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1., Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E, Structure. 2006 Feb;14(2):173-83. PMID:[http:// | + | Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1., Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E, Structure. 2006 Feb;14(2):173-83. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16472737 16472737] |
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
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[[Category: serine/threonine protein kinase; mark; par-1; kin1; uba domain]] | [[Category: serine/threonine protein kinase; mark; par-1; kin1; uba domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:37:27 2008'' |
Revision as of 13:37, 20 March 2008
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| , resolution 3.105Å | |||||||
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| Gene: | MARK2 (Rattus norvegicus) | ||||||
| Activity: | Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Catalytic and ubiqutin-associated domains of MARK2/PAR-1: K82R mutant
Overview
The Ser/Thr kinase MARK2 phosphorylates tau protein at sites that cause detachment from microtubules in Alzheimer neurofibrillary degeneration. Homologs of MARK2 include Par-1 in C. elegans and Drosophila, which generates embryonic polarity. We report the X-ray structure of the catalytic and ubiquitin-associated domains (UBA) of human MARK2. The activity was altered by mutations in the ATP binding site and/or activation loop. The catalytic domain shows the small and large lobes typical of kinases. The substrate cleft is in an inactive, open conformation in the inactivated and the wild-type structure. The UBA domain is attached via a taut linker to the large lobe of the kinase domain and leans against a hydrophobic patch on the small lobe. The UBA structure is unusual because the orientation of its third helix is inverted, relative to previous structures. Possible implications of the structure for the regulation of kinase activity are discussed.
About this Structure
1ZMV is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1., Panneerselvam S, Marx A, Mandelkow EM, Mandelkow E, Structure. 2006 Feb;14(2):173-83. PMID:16472737
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