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1znh

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[[Image:1znh.gif|left|200px]]<br /><applet load="1znh" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1znh.gif|left|200px]]
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caption="1znh, resolution 2.1&Aring;" />
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'''Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex'''<br />
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{{Structure
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|PDB= 1znh |SIZE=350|CAPTION= <scene name='initialview01'>1znh</scene>, resolution 2.1&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene> and <scene name='pdbligand=OC9:OCTAN-1-OL'>OC9</scene>
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|ACTIVITY=
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|GENE= MUP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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}}
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'''Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ZNH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=CD:'>CD</scene> and <scene name='pdbligand=OC9:'>OC9</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNH OCA].
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1ZNH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNH OCA].
==Reference==
==Reference==
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Strong solute-solute dispersive interactions in a protein-ligand complex., Malham R, Johnstone S, Bingham RJ, Barratt E, Phillips SE, Laughton CA, Homans SW, J Am Chem Soc. 2005 Dec 7;127(48):17061-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16316253 16316253]
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Strong solute-solute dispersive interactions in a protein-ligand complex., Malham R, Johnstone S, Bingham RJ, Barratt E, Phillips SE, Laughton CA, Homans SW, J Am Chem Soc. 2005 Dec 7;127(48):17061-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16316253 16316253]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: lipocalin]]
[[Category: lipocalin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:37:43 2008''

Revision as of 13:37, 20 March 2008

Image:1znh.gif


PDB ID 1znh

Drag the structure with the mouse to rotate
, resolution 2.1Å
Ligands: and
Gene: MUP1 (Mus musculus)
Coordinates: save as pdb, mmCIF, xml



Strong Solute-Solute Dispersive Interactions in a Protein-Ligand Complex


Overview

The contributions of solute-solute dispersion interactions to binding thermodynamics have generally been thought to be small, due to the surmised equality between solute-solvent dispersion interactions prior to the interaction versus solute-solute dispersion interactions following the interaction. The thermodynamics of binding of primary alcohols to the major urinary protein (MUP-I) indicate that this general assumption is not justified. The enthalpy of binding becomes more favorable with increasing chain length, whereas the entropy of binding becomes less favorable, both parameters showing a linear dependence. Despite the hydrophobicity of the interacting species, these data show that binding is not dominated by the classical hydrophobic effect, but can be attributed to favorable ligand-protein dispersion interactions.

About this Structure

1ZNH is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Strong solute-solute dispersive interactions in a protein-ligand complex., Malham R, Johnstone S, Bingham RJ, Barratt E, Phillips SE, Laughton CA, Homans SW, J Am Chem Soc. 2005 Dec 7;127(48):17061-7. PMID:16316253

Page seeded by OCA on Thu Mar 20 15:37:43 2008

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