1zoq

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[[Image:1zoq.gif|left|200px]]<br /><applet load="1zoq" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1zoq.gif|left|200px]]
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caption="1zoq, resolution 2.37&Aring;" />
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'''IRF3-CBP complex'''<br />
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{{Structure
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|PDB= 1zoq |SIZE=350|CAPTION= <scene name='initialview01'>1zoq</scene>, resolution 2.37&Aring;
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|SITE=
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|LIGAND=
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|ACTIVITY= [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48]
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|GENE= IRF3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), CREBBP, CBP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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}}
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'''IRF3-CBP complex'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ZOQ is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOQ OCA].
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1ZOQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOQ OCA].
==Reference==
==Reference==
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IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16154077 16154077]
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IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16154077 16154077]
[[Category: Histone acetyltransferase]]
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: transferase]]
[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:38:03 2008''

Revision as of 13:38, 20 March 2008

Image:1zoq.gif


PDB ID 1zoq

Drag the structure with the mouse to rotate
, resolution 2.37Å
Gene: IRF3 (Homo sapiens), CREBBP, CBP (Homo sapiens)
Activity: Histone acetyltransferase, with EC number 2.3.1.48
Coordinates: save as pdb, mmCIF, xml



IRF3-CBP complex


Contents

Overview

Interferon regulatory factor (IRF) 3 plays a critical role in triggering the activation of interferon antiviral genes. The structure of IRF-3 in association with the CBP/p300 coactivator by in this issue of Structure illuminates the mechanism of IRF activation and the structural flexibilities inherent in CBP/p300.

Disease

Known diseases associated with this structure: Blue-cone monochromacy OMIM:[303900], Colorblindness, protan OMIM:[303900], Rubenstein-Taybi syndrome OMIM:[600140]

About this Structure

1ZOQ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

IRF-3 releases its inhibitions., Hiscott J, Lin R, Structure. 2005 Sep;13(9):1235-6. PMID:16154077

Page seeded by OCA on Thu Mar 20 15:38:03 2008

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OCA

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