1zoy

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[[Image:1zoy.gif|left|200px]]<br /><applet load="1zoy" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1zoy.gif|left|200px]]
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caption="1zoy, resolution 2.4&Aring;" />
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'''Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms'''<br />
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{{Structure
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|PDB= 1zoy |SIZE=350|CAPTION= <scene name='initialview01'>1zoy</scene>, resolution 2.4&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=F3S:FE3-S4+CLUSTER'>F3S</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=EPH:L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE'>EPH</scene> and <scene name='pdbligand=UQ1:UBIQUINONE-1'>UQ1</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Succinate_dehydrogenase_(ubiquinone) Succinate dehydrogenase (ubiquinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.1 1.3.5.1]
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|GENE=
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}}
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'''Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ZOY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=FAD:'>FAD</scene>, <scene name='pdbligand=FES:'>FES</scene>, <scene name='pdbligand=SF4:'>SF4</scene>, <scene name='pdbligand=F3S:'>F3S</scene>, <scene name='pdbligand=HEM:'>HEM</scene>, <scene name='pdbligand=EPH:'>EPH</scene> and <scene name='pdbligand=UQ1:'>UQ1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Succinate_dehydrogenase_(ubiquinone) Succinate dehydrogenase (ubiquinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.1 1.3.5.1] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOY OCA].
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1ZOY is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZOY OCA].
==Reference==
==Reference==
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Crystal structure of mitochondrial respiratory membrane protein complex II., Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z, Cell. 2005 Jul 1;121(7):1043-57. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15989954 15989954]
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Crystal structure of mitochondrial respiratory membrane protein complex II., Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z, Cell. 2005 Jul 1;121(7):1043-57. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15989954 15989954]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Succinate dehydrogenase (ubiquinone)]]
[[Category: Succinate dehydrogenase (ubiquinone)]]
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[[Category: ubiquinone oxidoreductase]]
[[Category: ubiquinone oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:38:11 2008''

Revision as of 13:38, 20 March 2008

Image:1zoy.gif


PDB ID 1zoy

Drag the structure with the mouse to rotate
, resolution 2.4Å
Ligands: , , , , , and
Activity: Succinate dehydrogenase (ubiquinone), with EC number 1.3.5.1
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Mitochondrial Respiratory Complex II from porcine heart at 2.4 Angstroms


Overview

The mitochondrial respiratory Complex II or succinate:ubiquinone oxidoreductase (SQR) is an integral membrane protein complex in both the tricarboxylic acid cycle and aerobic respiration. Here we report the first crystal structure of Complex II from porcine heart at 2.4 A resolution and its complex structure with inhibitors 3-nitropropionate and 2-thenoyltrifluoroacetone (TTFA) at 3.5 A resolution. Complex II is comprised of two hydrophilic proteins, flavoprotein (Fp) and iron-sulfur protein (Ip), and two transmembrane proteins (CybL and CybS), as well as prosthetic groups required for electron transfer from succinate to ubiquinone. The structure correlates the protein environments around prosthetic groups with their unique midpoint redox potentials. Two ubiquinone binding sites are discussed and elucidated by TTFA binding. The Complex II structure provides a bona fide model for study of the mitochondrial respiratory system and human mitochondrial diseases related to mutations in this complex.

About this Structure

1ZOY is a Protein complex structure of sequences from Sus scrofa. Full crystallographic information is available from OCA.

Reference

Crystal structure of mitochondrial respiratory membrane protein complex II., Sun F, Huo X, Zhai Y, Wang A, Xu J, Su D, Bartlam M, Rao Z, Cell. 2005 Jul 1;121(7):1043-57. PMID:15989954

Page seeded by OCA on Thu Mar 20 15:38:11 2008

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