1zpi

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[[Image:1zpi.gif|left|200px]]<br /><applet load="1zpi" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1zpi.gif|left|200px]]
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caption="1zpi, resolution 1.60&Aring;" />
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'''Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8224 complexed with CGCGAATTCGCG'''<br />
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{{Structure
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|PDB= 1zpi |SIZE=350|CAPTION= <scene name='initialview01'>1zpi</scene>, resolution 1.60&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=SN9:8-METHOXY-1-METHYL-4-(4-(4-(1-METHYLPYRIDINIUM-4-YLAMINO)PHENYLCARBAMOYL)PHENYLAMINO)QUINOLINIUM'>SN9</scene> and <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8224 complexed with CGCGAATTCGCG'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ZPI is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=SN9:'>SN9</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPI OCA].
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1ZPI is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZPI OCA].
==Reference==
==Reference==
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Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution., Adams A, Leong C, Denny WA, Guss JM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1348-53. Epub 2005, Sep 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16204886 16204886]
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Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution., Adams A, Leong C, Denny WA, Guss JM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1348-53. Epub 2005, Sep 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16204886 16204886]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Adams, A.]]
[[Category: Adams, A.]]
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[[Category: minor groove binding complex]]
[[Category: minor groove binding complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:17:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:38:24 2008''

Revision as of 13:38, 20 March 2008

Image:1zpi.gif


PDB ID 1zpi

Drag the structure with the mouse to rotate
, resolution 1.60Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8224 complexed with CGCGAATTCGCG


Overview

The structures of the complexes formed between two anticancer minor-groove-binding quinolinium quaternary salts and the dodecamer d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8 Angstrom. The complexes crystallized in space group P2(1)2(1)2(1) and the structures are isomorphous with previously solved dodecamer structures. The ligands both bind in the central AT region of the minor groove and although the crystallization conditions and structures of the ligands are very similar, they bind in opposing orientations. The structures are compared with two previously published structures of quinolinium quaternary salts, refined at 2.5 Angstrom resolution, complexed with d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA.

About this Structure

1ZPI is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution., Adams A, Leong C, Denny WA, Guss JM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1348-53. Epub 2005, Sep 28. PMID:16204886

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