1zq3
From Proteopedia
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| - | [[Image:1zq3.gif|left|200px]] | + | [[Image:1zq3.gif|left|200px]] |
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| - | '''NMR Solution Structure of the Bicoid Homeodomain Bound to the Consensus DNA Binding Site TAATCC''' | + | {{Structure |
| + | |PDB= 1zq3 |SIZE=350|CAPTION= <scene name='initialview01'>1zq3</scene> | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= bcd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster]) | ||
| + | }} | ||
| + | |||
| + | '''NMR Solution Structure of the Bicoid Homeodomain Bound to the Consensus DNA Binding Site TAATCC''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZQ3 is a [ | + | 1ZQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZQ3 OCA]. |
==Reference== | ==Reference== | ||
| - | The solution structure of the native K50 Bicoid homeodomain bound to the consensus TAATCC DNA-binding site., Baird-Titus JM, Clark-Baldwin K, Dave V, Caperelli CA, Ma J, Rance M, J Mol Biol. 2006 Mar 10;356(5):1137-51. Epub 2005 Dec 22. PMID:[http:// | + | The solution structure of the native K50 Bicoid homeodomain bound to the consensus TAATCC DNA-binding site., Baird-Titus JM, Clark-Baldwin K, Dave V, Caperelli CA, Ma J, Rance M, J Mol Biol. 2006 Mar 10;356(5):1137-51. Epub 2005 Dec 22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16406070 16406070] |
[[Category: Drosophila melanogaster]] | [[Category: Drosophila melanogaster]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: translational control]] | [[Category: translational control]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:38:28 2008'' |
Revision as of 13:38, 20 March 2008
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| Gene: | bcd (Drosophila melanogaster) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
NMR Solution Structure of the Bicoid Homeodomain Bound to the Consensus DNA Binding Site TAATCC
Overview
The solution structure of the homeodomain of the Drosophila morphogenic protein Bicoid (Bcd) complexed with a TAATCC DNA site is described. Bicoid is the only known protein that uses a homeodomain to regulate translation, as well as transcription, by binding to both RNA and DNA during early Drosophila development; in addition, the Bcd homeodomain can recognize an array of different DNA sites. The dual functionality and broad recognition capabilities signify that the Bcd homeodomain may possess unique structural/dynamic properties. Bicoid is the founding member of the K50 class of homeodomain proteins, containing a lysine residue at the critical 50th position (K50) of the homeodomain sequence, a residue required for DNA and RNA recognition; Bcd also has an arginine residue at the 54th position (R54), which is essential for RNA recognition. Bcd is the only known homeodomain with the K50/R54 combination of residues. The Bcd structure indicates that this homeodomain conforms to the conserved topology of the homeodomain motif, but exhibits a significant variation from other homeodomain structures at the end of helix 1. A key result is the observation that the side-chains of the DNA-contacting residues K50, N51 and R54 all show strong signs of flexibility in the protein-DNA interface. This finding is supportive of the adaptive-recognition theory of protein-DNA interactions.
About this Structure
1ZQ3 is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
The solution structure of the native K50 Bicoid homeodomain bound to the consensus TAATCC DNA-binding site., Baird-Titus JM, Clark-Baldwin K, Dave V, Caperelli CA, Ma J, Rance M, J Mol Biol. 2006 Mar 10;356(5):1137-51. Epub 2005 Dec 22. PMID:16406070
Page seeded by OCA on Thu Mar 20 15:38:28 2008
