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1ci6
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ci6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci6 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ci6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1ci6 RCSB], [http://www.ebi.ac.uk/pdbsum/1ci6 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ATF4_HUMAN ATF4_HUMAN]] Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA.<ref>PMID:15775988</ref> <ref>PMID:16682973</ref> <ref>PMID:18940792</ref> [[http://www.uniprot.org/uniprot/CEBPB_MOUSE CEBPB_MOUSE]] Involved in interleukin-6 signal transduction, including the transcriptional activation of acute-phase genes. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:19641492</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 20:51, 24 December 2014
TRANSCRIPTION FACTOR ATF4-C/EBP BETA BZIP HETERODIMER
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