4u6r
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u6r RCSB], [http://www.ebi.ac.uk/pdbsum/4u6r PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4u6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4u6r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4u6r RCSB], [http://www.ebi.ac.uk/pdbsum/4u6r PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN]] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
| - | [[Category: Mohr, C | + | [[Category: Mohr, C]] |
[[Category: Endoribonuclease]] | [[Category: Endoribonuclease]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 21:03, 24 December 2014
Crystal structure of human IRE1 cytoplasmic domains in complex with a sulfonamide inhibitor.
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