2kfd
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kfd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kfd RCSB], [http://www.ebi.ac.uk/pdbsum/2kfd PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kfd OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kfd RCSB], [http://www.ebi.ac.uk/pdbsum/2kfd PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PRP40_YEAST PRP40_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U1. Two commitment complexes, CC1 and CC2, have been defined in yeast. CC1 is a basal complex dependent only on the 5' splice site. CC2 is a complex of lower mobility and is dependent on a branchpoint as well as a 5' splice site region. This protein is involved in CC2 formation where it binds to the branchpoint binding protein MSL5, bridging the U1 snRNP-associated 5' splice site and the MSL5-associated branch point 3' intron splice site.<ref>PMID:9150140</ref> <ref>PMID:10978320</ref> <ref>PMID:15020406</ref> | ||
==See Also== | ==See Also== | ||
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]] | *[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Bonet, R | + | [[Category: Bonet, R]] |
| - | [[Category: Macias, M | + | [[Category: Macias, M]] |
| - | [[Category: Morales, B | + | [[Category: Morales, B]] |
| - | [[Category: Ruiz, L | + | [[Category: Ruiz, L]] |
[[Category: Ff domain]] | [[Category: Ff domain]] | ||
[[Category: Mrna processing]] | [[Category: Mrna processing]] | ||
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[[Category: Prp40]] | [[Category: Prp40]] | ||
[[Category: Ribonucleoprotein]] | [[Category: Ribonucleoprotein]] | ||
| - | [[Category: Saccharomyces cerevisiae]] | ||
Revision as of 21:08, 24 December 2014
Prp40 FF4 domain
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