2lr9
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lr9 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lr9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lr9 RCSB], [http://www.ebi.ac.uk/pdbsum/2lr9 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CA1A_CONTU CA1A_CONTU]] Allosteric inhibitor of alpha-1B adrenergic receptors (ADRA1B). Binds to an allosteric modulatory site on transmembrane helix 6 and 7 at the base of extracellular loop 3 of ADRA1B (PubMed:23184947). Also weekly inhibits alpha-1A (ADRA1A) and alpha-1D (ADRA1D) adrenergic receptors in a competive manner (PubMed:15194691). Potently inhibits contractions of vas deferens, spleen and aorta in response to noradrenaline (PubMed:15680270).<ref>PMID:11528421</ref> <ref>PMID:12824165</ref> <ref>PMID:15194691</ref> <ref>PMID:15680270</ref> <ref>PMID:23184947</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 21:11, 24 December 2014
High-resolution solution NMR structure of the rho-conotoxin TIA.
| |||||||||||
