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1qhi
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1qhi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QHI FirstGlance]. <br> | <table><tr><td colspan='2'>[[1qhi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QHI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QHI FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BPG:9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE'>BPG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BPG:9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE'>BPG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qhi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qhi RCSB], [http://www.ebi.ac.uk/pdbsum/1qhi PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qhi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1qhi RCSB], [http://www.ebi.ac.uk/pdbsum/1qhi PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
| - | [[Category: Batuwangala, T | + | [[Category: Batuwangala, T]] |
| - | [[Category: Bennett, M S | + | [[Category: Bennett, M S]] |
| - | [[Category: Champness, J N | + | [[Category: Champness, J N]] |
| - | [[Category: Rutherford, T | + | [[Category: Rutherford, T]] |
| - | [[Category: Sanderson, M R | + | [[Category: Sanderson, M R]] |
| - | [[Category: Summers, W C | + | [[Category: Summers, W C]] |
| - | [[Category: Sun, H | + | [[Category: Sun, H]] |
| - | [[Category: Wien, F | + | [[Category: Wien, F]] |
| - | [[Category: Wright, G | + | [[Category: Wright, G]] |
[[Category: Alphaherpesvirinae novel inhibitor]] | [[Category: Alphaherpesvirinae novel inhibitor]] | ||
[[Category: Ds-dna enveloped viruse]] | [[Category: Ds-dna enveloped viruse]] | ||
Revision as of 21:18, 24 December 2014
HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE
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