1zvb
From Proteopedia
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| - | [[Image:1zvb.gif|left|200px]] | + | [[Image:1zvb.gif|left|200px]] |
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| - | '''A structure-based mechanism of SARS virus membrane fusion''' | + | {{Structure |
| + | |PDB= 1zvb |SIZE=350|CAPTION= <scene name='initialview01'>1zvb</scene>, resolution 1.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human SARS coronavirus]) | ||
| + | }} | ||
| + | |||
| + | '''A structure-based mechanism of SARS virus membrane fusion''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZVB is a [ | + | 1ZVB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZVB OCA]. |
==Reference== | ==Reference== | ||
| - | Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein., Deng Y, Liu J, Zheng Q, Yong W, Lu M, Structure. 2006 May;14(5):889-99. PMID:[http:// | + | Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein., Deng Y, Liu J, Zheng Q, Yong W, Lu M, Structure. 2006 May;14(5):889-99. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16698550 16698550] |
[[Category: Human sars coronavirus]] | [[Category: Human sars coronavirus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Yong, W.]] | [[Category: Yong, W.]] | ||
[[Category: Zheng, Q.]] | [[Category: Zheng, Q.]] | ||
| - | [[Category: coiled | + | [[Category: coiled coil]] |
[[Category: conformational change]] | [[Category: conformational change]] | ||
[[Category: membrane fusion]] | [[Category: membrane fusion]] | ||
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[[Category: virus entry]] | [[Category: virus entry]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:40:13 2008'' |
Revision as of 13:40, 20 March 2008
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| , resolution 1.70Å | |||||||
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| Gene: | S (Human SARS coronavirus) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
A structure-based mechanism of SARS virus membrane fusion
Overview
Entry of SARS coronavirus into its target cell requires large-scale structural transitions in the viral spike (S) glycoprotein in order to induce fusion of the virus and cell membranes. Here we describe the identification and crystal structures of four distinct alpha-helical domains derived from the highly conserved heptad-repeat (HR) regions of the S2 fusion subunit. The four domains are an antiparallel four-stranded coiled coil, a parallel trimeric coiled coil, a four-helix bundle, and a six-helix bundle that is likely the final fusogenic form of the protein. When considered together, the structural and thermodynamic features of the four domains suggest a possible mechanism whereby the HR regions, initially sequestered in the native S glycoprotein spike, are released and refold sequentially to promote membrane fusion. Our results provide a structural framework for understanding the control of membrane fusion and should guide efforts to intervene in the SARS coronavirus entry process.
About this Structure
1ZVB is a Single protein structure of sequence from Human sars coronavirus. Full crystallographic information is available from OCA.
Reference
Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein., Deng Y, Liu J, Zheng Q, Yong W, Lu M, Structure. 2006 May;14(5):889-99. PMID:16698550
Page seeded by OCA on Thu Mar 20 15:40:13 2008
