1zv8

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[[Image:1zv8.gif|left|200px]]<br /><applet load="1zv8" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:1zv8.gif|left|200px]]
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caption="1zv8, resolution 1.94&Aring;" />
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'''A structure-based mechanism of SARS virus membrane fusion'''<br />
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{{Structure
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|PDB= 1zv8 |SIZE=350|CAPTION= <scene name='initialview01'>1zv8</scene>, resolution 1.94&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=NA:SODIUM ION'>NA</scene>
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|ACTIVITY=
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|GENE= S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Human SARS coronavirus]), S ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=227859 SARS coronavirus])
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}}
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'''A structure-based mechanism of SARS virus membrane fusion'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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1ZV8 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus] and [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus] with <scene name='pdbligand=CAC:'>CAC</scene>, <scene name='pdbligand=ACT:'>ACT</scene>, <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=NA:'>NA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV8 OCA].
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1ZV8 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus] and [http://en.wikipedia.org/wiki/Sars_coronavirus Sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZV8 OCA].
==Reference==
==Reference==
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Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein., Deng Y, Liu J, Zheng Q, Yong W, Lu M, Structure. 2006 May;14(5):889-99. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16698550 16698550]
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Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein., Deng Y, Liu J, Zheng Q, Yong W, Lu M, Structure. 2006 May;14(5):889-99. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16698550 16698550]
[[Category: Human sars coronavirus]]
[[Category: Human sars coronavirus]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: NA]]
[[Category: NA]]
[[Category: ZN]]
[[Category: ZN]]
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[[Category: coiled coils]]
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[[Category: coiled coil]]
[[Category: conformational change]]
[[Category: conformational change]]
[[Category: membrane fusion]]
[[Category: membrane fusion]]
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[[Category: virus entry]]
[[Category: virus entry]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:19:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:40:14 2008''

Revision as of 13:40, 20 March 2008

Image:1zv8.gif


PDB ID 1zv8

Drag the structure with the mouse to rotate
, resolution 1.94Å
Ligands: , , and
Gene: S (Human SARS coronavirus), S (SARS coronavirus)
Coordinates: save as pdb, mmCIF, xml



A structure-based mechanism of SARS virus membrane fusion


Overview

Entry of SARS coronavirus into its target cell requires large-scale structural transitions in the viral spike (S) glycoprotein in order to induce fusion of the virus and cell membranes. Here we describe the identification and crystal structures of four distinct alpha-helical domains derived from the highly conserved heptad-repeat (HR) regions of the S2 fusion subunit. The four domains are an antiparallel four-stranded coiled coil, a parallel trimeric coiled coil, a four-helix bundle, and a six-helix bundle that is likely the final fusogenic form of the protein. When considered together, the structural and thermodynamic features of the four domains suggest a possible mechanism whereby the HR regions, initially sequestered in the native S glycoprotein spike, are released and refold sequentially to promote membrane fusion. Our results provide a structural framework for understanding the control of membrane fusion and should guide efforts to intervene in the SARS coronavirus entry process.

About this Structure

1ZV8 is a Protein complex structure of sequences from Human sars coronavirus and Sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein., Deng Y, Liu J, Zheng Q, Yong W, Lu M, Structure. 2006 May;14(5):889-99. PMID:16698550

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