We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
1zhq
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zhq RCSB], [http://www.ebi.ac.uk/pdbsum/1zhq PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1zhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zhq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1zhq RCSB], [http://www.ebi.ac.uk/pdbsum/1zhq PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MVL_MICVR MVL_MICVR]] Carbohydrate-binding protein that binds oligomannosides such as Man(6)GlcNAc(2) with sub-micromolar affinities. The specificity of MVL is unique in that its minimal target comprises the Man-alpha-(1->6)-Man-beta-(1->4)-GlcNAc-beta-(1->4)-GlcNAc tetrasaccharide core (Man(2)A) found in N-linked oligomannosides. Displays hemagglutininating activity on rabbit, horse and hen erythrocytes. This activity is inhibited by yeast mannan. Does not bind mono- and disachharides. Inhibits HIV-1 envelope-mediated cell fusion at nanomolar concentrations through carbohydrate-mediated interactions with high-mannose residues on the surface of the HIV envelope glycoprotein gp120. Unexpectedly for a lectin, one of the 2 oligomannose binding sites of MVL can catalyze the cleavage of chitin fragments (such as chitotriose, i.e. GlcNAc(3) or GlcNAc-beta-(1->4)-GlcNAcbeta-(1->4)-GlcNAc, and chitotetraose, i.e. GlcNAc(4)) to GlcNAc. This weak glycosidase activity is restricted to the C-terminal carbohydrate-binding site. Does not cleave Man(3)GlcNAc(2) or the tetrasaccharide Man(2)A. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Microcystis viridis]] | [[Category: Microcystis viridis]] | ||
| - | [[Category: Bewley, C A | + | [[Category: Bewley, C A]] |
| - | [[Category: Cai, M | + | [[Category: Cai, M]] |
| - | [[Category: Clore, G M | + | [[Category: Clore, G M]] |
| - | [[Category: Lee, J Y | + | [[Category: Lee, J Y]] |
| - | [[Category: Williams, D C | + | [[Category: Williams, D C]] |
[[Category: Carbohydrate binding]] | [[Category: Carbohydrate binding]] | ||
[[Category: Cyanobacteria]] | [[Category: Cyanobacteria]] | ||
Revision as of 21:23, 24 December 2014
Crystal structure of apo MVL
| |||||||||||
