1wsz

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1wsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WSZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1wsz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1WSZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lz0|1lz0]], [[1wt0|1wt0]], [[1wt1|1wt1]], [[1wt2|1wt2]], [[1wt3|1wt3]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lz0|1lz0]], [[1wt0|1wt0]], [[1wt1|1wt1]], [[1wt2|1wt2]], [[1wt3|1wt3]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glycoprotein-fucosylgalactoside_alpha-N-acetylgalactosaminyltransferase Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.40 2.4.1.40] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wsz RCSB], [http://www.ebi.ac.uk/pdbsum/1wsz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1wsz RCSB], [http://www.ebi.ac.uk/pdbsum/1wsz PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
[[Category: Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Barry, C H.]]
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[[Category: Barry, C H]]
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[[Category: Blancher, A.]]
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[[Category: Blancher, A]]
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[[Category: Borisova, S N.]]
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[[Category: Borisova, S N]]
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[[Category: Evans, S V.]]
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[[Category: Evans, S V]]
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[[Category: Lee, H J.]]
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[[Category: Lee, H J]]
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[[Category: Palcic, M M.]]
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[[Category: Palcic, M M]]
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[[Category: Seto, N O.L.]]
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[[Category: Seto, N O.L]]
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[[Category: Zheng, R B.]]
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[[Category: Zheng, R B]]
[[Category: Transferase]]
[[Category: Transferase]]

Revision as of 21:25, 24 December 2014

Mutant human ABO(H) blood group transferase A

1wsz, resolution 1.59Å

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