1zwl
From Proteopedia
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| - | [[Image:1zwl.gif|left|200px]] | + | [[Image:1zwl.gif|left|200px]] |
| - | + | ||
| - | '''Structure of WrbA from Pseudomonas aeruginosa in complex with FMN''' | + | {{Structure |
| + | |PDB= 1zwl |SIZE=350|CAPTION= <scene name='initialview01'>1zwl</scene>, resolution 2.80Å | ||
| + | |SITE= | ||
| + | |LIGAND= <scene name='pdbligand=FMN:FLAVIN MONONUCLEOTIDE'>FMN</scene> | ||
| + | |ACTIVITY= | ||
| + | |GENE= wrba ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 Pseudomonas aeruginosa]) | ||
| + | }} | ||
| + | |||
| + | '''Structure of WrbA from Pseudomonas aeruginosa in complex with FMN''' | ||
| + | |||
==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ZWL is a [ | + | 1ZWL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZWL OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide., Gorman J, Shapiro L, Protein Sci. 2005 Dec;14(12):3004-12. PMID:[http:// | + | Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide., Gorman J, Shapiro L, Protein Sci. 2005 Dec;14(12):3004-12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16322580 16322580] |
[[Category: Pseudomonas aeruginosa]] | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: protein structure initiative]] | [[Category: protein structure initiative]] | ||
[[Category: psi]] | [[Category: psi]] | ||
| - | [[Category: structural | + | [[Category: structural genomic]] |
[[Category: wrba]] | [[Category: wrba]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:40:43 2008'' |
Revision as of 13:40, 20 March 2008
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| , resolution 2.80Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | wrba (Pseudomonas aeruginosa) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of WrbA from Pseudomonas aeruginosa in complex with FMN
Overview
The tryptophan repressor binding protein WrbA binds to the tryptophan repressor protein TrpR. Although the biological role of WrbA remains unclear, it has been proposed to function in enhancing the stability of TrpR-DNA complexes. Sequence database analysis has identified WrbA as a founding member of a flavodoxin-like family of proteins. Here we present crystal structures of WrbA from Deinococcus radiodurans and Pseudomonas aeruginosa and their complexes with flavin mononucleotide. The protomer structure is similar to that of previously determined long-chain flavodoxins; however, each contains a conserved inserted region unique to the WrbA family. Interestingly, each WrbA protein forms a homotetramer with 222 symmetry, unique among flavodoxin-like proteins, in which each protomer binds one flavin mononucleotide cofactor molecule.
About this Structure
1ZWL is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
Crystal structures of the tryptophan repressor binding protein WrbA and complexes with flavin mononucleotide., Gorman J, Shapiro L, Protein Sci. 2005 Dec;14(12):3004-12. PMID:16322580
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